Active Concept ProBiocin V

Antimicrobial, Redness Reduction, Scalp Care

6/2/20243 min read

smiling woman in brown top holding hairs
smiling woman in brown top holding hairs

Active Concepts ProBiocin V


Scalp care is a prevalent branch of hair care, as a healthy scalp means healthy hair growth. However, dandruff has been shown to effect approximately 50% of the population, regardless of gender or ethnicity, driving consumer’s interests in products that can restore balance to an "unhealthy” scalp. Malassezia spp. has been shown to play a key role in the pathogenesis of dandruff. A study performed on a group of dandruff patients resulted in 84% of participants having a species of Malassezia present on the scalp. Inspired by dandruff related irritation, research has driven product development to address Malassezia and balance the scalp microbiome.

The culturing of the probiotic bacterium Lactobacillus acidophilus, supported by prebiotic nutrients, diminishes the presence of Malassezia on the scalp, while presenting a new global approach to non-traditional preservative technologies. ProBiocin V harnesses the benefits of prebiotic oligosaccharides to offer a competitive edge to commensal microorganisms in their natural ecosystem. This optimized production method of supplementing the growth media aids in the production of postbiotic bacteriocin peptides, capable of delivering moisturizing and redness reduction benefits to soothe an irritated scalp.

Current efforts to reduce the prevalence of microorganisms associated with dandruff, involve the development of scalp and hair care products able to alleviate caustic pathogenic microorganisms, while relieving the scalp from itchiness. Traditional preservatives, frequently used in hair care applications, have been shown to be detrimental to both commensal and pathogenic bacteria living on the skin and scalp

Consumer concerns regarding the use of synthetic preservative systems, such as parabens, formaldehyde donors and phenoxyethanol, have pushed formulators to seek out alternative means of preservation that can provide broad spectrum antimicrobial protection and a multifunctional activity. Consumers often perceive traditional preservative systems as being associated with sensitization. ProBiocin V is a technology able to diminish these concerns, while providing efficacious benefits against scalp irritation. The produced bacteriocin peptides are also capable of providing broad spectrum antimicrobial protection in order to maintain the integrity of the formulation. ProBiocin V acts as a multifunctional system that boosts preservation while delivering soothing benefits to the scalp. ProBiocin V is also vegan and compliant in many global markets.

Veganism is a popular trend in the cosmetic industry as well. As consumers are making lifestyle choices that make them feel healthier, the same logic applies to the products they use. Although you do not have to be vegan to use vegan products, consumers are beginning to pay more attention to what goes into the products they use and how these products will benefit them long-term. While shifting towards animal alternatives and away from ethical concerns, sacrificing the quality of ingredients is not an option when it comes to treating common cosmetic concerns such as moisturization and redness.

Active Micro Technologies has developed a full line of products derived from naturally occurring compounds that provide broad spectrum antimicrobial protection. As a result, these novel natural antimicrobials are considered self-preserving cosmetic actives and therefore can be used as consumer-friendly alternatives to synthetic preservatives in a wide range of cosmetic applications


Lactobacillus acidophilus, harnessing probiotic attributes, produces postbiotic antimicrobial peptides known as bacteriocins. To achieve this, prebiotic chicory oligosaccharide fructans are supplemented into the Lactobacillus growth media during fermentation. Lysozyme is then used to facilitate controlled cell lysis of the ferment filtrate. When applied to the scalp, beneficial microorganisms are enriched and the microbiota is modulated, in effort to achieve a homeostatic environment. The Lactobacillus derived peptides work to condition the scalp, while reducing pathogenic microorganisms to soothe irritation.


Acting as a multifunctional system that boosts preservation while delivering soothing benefits to the scalp, ProBiocin V utilizes the properties of prebiotic oligosaccharides as an approach to postbiotic bacteriocin procurement to deliver scalp moisturization and redness reduction.


ProBiocin V can be used in a wide range of cosmetic products, however to ensure optimum results we recommend using the following guidelines. Incorporate the product into formulations at a pH between 3 and 8, during the cooling phase of the process at temperatures lower than 40°C

Storage: Store in a dry place at temperatures between 16 and 32°C. Do not freeze.

Shelf life: 12 months, properly stored, in sealed container.

This product should be added to a formulation at the recommended usage rated.

INCI: Lactobacillus Ferment Lysate

Use Levels: 2.0% - 4.0%

Solubility: Water Soluble, Alcohol Soluble

Appearance: Clear to Slightly Hazy, Colorless to Yellow Liquid

pH (direct): 4.0 - 11.0
Bacteriocins (HPLC): 5.00% - 10.00%

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ProBiocin V from Active Concepts visit

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